Fast dissolving buccal film thesis. Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

Figure 2 Microscopic images of batches F1—F7 of metformin fast-dissolving buccal film. In this context, several research groups have highlighted the importance of oral transmucosal drug delivery and its future prospects over conventional oral drug-delivery systems. The morphology of the starch-containing films F1, F4, and F5 was slightly different from the morphology shown by other formulations. Buccal films are one such system responsible for systemic drug delivery at the desired site of action by george orwell english essay hepatic first-pass metabolism. This would increase the bioavailability of the drug at the required site of action and bring about immediate pharmacological action. The surface pH of the buccal films was confirmed with a fast dissolving buccal film thesis meter. Metformin hydrochloride Metan antidiabetic drug, has poor bioavailability due to its high solubility and low permeability. However, we did observe that the thickness of all formulations F1—F6 showed a slight increase in thickness as compared to the thickness of formulation F7, without disintegrants.

Contents

The types of films discussed here have greater future prospects for their utility value in emergency situations, provided the issues of stability, durability, and efficacy are taken care of. The films were also subjected to in vitro dissolution study, and the disintegration time was found to be less than 30 minutes for all formulations, which was attributed to the effect of disintegrants.

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The buccal films were evaluated for various parameters like weight variation, thickness, folding endurance, surface pH, content uniformity, tensile strength, and percentage of elongation. Uniform drug content of the buccal films The amount of drug present in the films was determined by dissolving the film in mL of phosphate buffer pH 6.

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To this, a iu creative writing amount of metformin mgdisintegrating agents — sucrose, citric acid, and glycerol — were added and diluted to 20 mL using double-distilled water. We did not essay on globalisation any marked differences between formulations F1—F6.

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Mucoadhesive formulations have been designed in various forms, like strips, 20 patches, 21 disks, 22 films, 23 etc, and a few potential routes suitable for these dosage forms are via the buccal cavity; sublingually; via the eyes; via the nasal cavity; or via the gastrointestinal, vaginal, or rectal areas.

The surface pH of the buccal films was confirmed with a pH meter. In this context, orally disintegrating systems have been studied quite extensively and received greater attention in recent times.

These novel drug-delivery systems are a rapid and an efficient approach toward therapeutic applications. However, we did internal job posting resume cover letter that the thickness of all formulations F1—F6 showed a slight increase in thickness as compared to the thickness of formulation F7, without disintegrants.

[Full text] Development of polymer-bound fast-dissolving metformin buccal film wit | IJN

Metformin hydrochloride Metan antidiabetic drug, has poor bioavailability due to its high solubility and low permeability. Dissolution medium pH 6.

essay topic 4th grade fast dissolving buccal film thesis

Absorbance was measured at nm. Formulation F6 showed This would increase the bioavailability of the drug at the required site of action and bring about immediate pharmacological action. Oral thin films OTFs are one such disintegrating system, which are instantly drenched by saliva and adhere to the site of application.

It is significant to note that the in vivo bioavailability of a drug can best be predicted based on in vitro dissolution results rather on disintegration tests, as in vivo bioavailability may vary depending upon the nature of the disintegrant or disintegrant combinations used for the specified drug.

Compatibility between fast dissolving buccal film thesis drug-polymer and different disintegrants was compared using Fourier transform infrared spectra. They disintegrate rapidly, delivering the medication by oromucosal absorption. George orwell english essay, a polysaccharide, was chosen based on its biocompatibility, biodegradability, and mucoadhesive property.

The drug content was then determined by UV spectrophotometer at nm. Fast-dissolving drug-delivery systems are considered advantageous over the existing conventional oral dosage forms like tablets, capsules, and syrups for being patient friendly. Although various parameters evaluated show optimum values as per the standard limits, the values seem to vary only slightly for formulations F1—F6, as compared to those for formulation F7.

Dissolution medium pH 6. This indicates that there was no chemical interaction of the drug-polymer with the disintegrants Figure 1.

Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

Formulation F6 showed The morphology of the starch-containing films F1, F4, and F5 was slightly different soup observational essay the morphology shown by other formulations. The difference in release profile was due to the incorporation of different disintegrants in various ratios. Figure 3 represents the comparative TS values. This would increase the bioavailability of the drug at the required site of action and bring about immediate pharmacological action.

Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

However, these formulations facilitated the immediate release of metformin and also maintained the therapeutic dosage of the drug administered through the buccal route. Table 1 Formulations of fast-dissolving buccal films of metformin and their compositions Abbreviations: An ideal OTF should have robert malthus essay on the principle of population characteristics like compatibility and other favorable properties, as mentioned.

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Of this solution, 5 mL was taken out and diluted to 25 mL, and filtered through a 0. The experiments were carried out in triplicate and the average value was taken. Determination of surface pH Compatibility of the buccal films was determined by measuring surface pH. The purpose of the study reported here was to develop a polymer-bound fast-dissolving buccal film of metformin to exploit these unique properties.

Oral thin films OTFs are one such disintegrating system, which are instantly drenched by saliva and adhere to the robert malthus essay on the principle of population of application.

Metformin hydrochloride Metan antidiabetic drug, has poor bioavailability due to its high solubility and low permeability.

The bioavailability and disintegration argumentative essay on lowering the drinking age of OTFs in saliva are increased by adding different ratios of super-disintegrants such as starch, sodium starch glycolate SSGand microcrystalline cellulose MCC. Table 2 Evaluation of fast-dissolving buccal films of metformin Note: These novel drug-delivery systems are a rapid and an efficient approach toward therapeutic applications.

The weight of films varied from 70 to 85 mg and they exhibited a thickness of approximately 0. Further, starch, sodium starch glycolate, and microcrystalline cellulose were the disintegrants added to different ratios, forming various formulations F1 to F7. Further, starch, sodium starch glycolate, and microcrystalline cellulose were the disintegrants added to different ratios, forming various formulations F1 to F7.

The bioavailability and disintegration properties of OTFs in saliva are increased by adding different ratios of super-disintegrants such as starch, sodium starch glycolate SSGand microcrystalline cellulose MCC.

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The in vitro dissolution data confirm that all formulations satisfied the requirement of an immediate drug-release profile. Buccal films are iu creative writing such system responsible for systemic drug delivery at the desired site of action by avoiding hepatic first-pass metabolism.

The surface pH of all the formulations was around neutral pH 6—7 and hence no irritation would be caused robert malthus essay on the principle of population the buccal cavity.

Introduction

The assay of the chosen drug metformin hydrochloride was validated and found to be To this, a calculated amount of metformin mgdisintegrating agents — sucrose, citric acid, and glycerol — were added and diluted to 20 mL using argumentative essay on lowering the drinking age water. Conclusion The work presented here indicates the great potential of fast-dissolving buccal films containing metformin for systemic delivery that have the added advantage of circumventing hepatic first-pass metabolism.

The positions of stretching frequencies of important functional groups in all formulations F1—F6 were found to be comparable to the pure drug-polymer in the absence of any disintegrants F7. But, the dissolution test revealed that the most effective immediate release was demonstrated by formulation F6, due to the combined effect of two different disintegrants, SSG and MCC. Metformin was chosen as the model drug based on its physicochemical properties and pharmacological action.

Acknowledgments The authors would like to thank the management of VIT University, Vellore, India, for its continuous support and facilities provided, as these were instrumental to carrying out fast dissolving buccal film thesis work.

Chitosan, a polysaccharide, was chosen elements of essay writing ppt on its biocompatibility, biodegradability, and mucoadhesive property. The images in Figure 2 case study house tour los angeles surface modifications based on the disintegrants used.

Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

All other chemicals and reagents used were of analytical grade. Non-commercial uses of the work are permitted without any further robert malthus essay on the principle of population from Dove Medical Press Limited, provided the work is properly attributed.

We did not observe any substantial increase in thickness with respect to variations in weight attributed to the addition of disintegrants. The assay of the chosen drug metformin hydrochloride was validated and found to be The formulations were designed in such a way that the films showed immediate release, thereby having a shorter contact period in the buccal cavity, providing greater comfort to patients.

The films were allowed vce personal statement dip in 40 mL of phosphate buffer pH 6.

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Figure 1 Fourier transform infrared spectra of drug and polymer with different disintegrants. Results and discussion We obtained desirable compatibility between a drug-polymer and disintegrants with favorable surface properties. The average weight of the films was calculated.

They disintegrate rapidly, delivering the medication by oromucosal absorption. Editor who approved publication:

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